Swollen eye is setback for blindness treatment using stem cells
A man in a flagship stem cell trial for age-related macular degeneration has swelling in his eye, but the cause is probably surgery – not stem cells
Boy is given new skin thanks to gene therapy
A medical team has successfully treated a child suffering from extensive skin damage using transplants derived from genetically modified stem cells. The boy is a so-called butterfly child: he suffers from epidermolysis bullosa, a genetic skin disease that had destroyed approximately 80 percent of his epidermis.
Researchers create first stem cells using CRISPR genome activation
In a scientific first, researchers have turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process.
In scientific first, researchers grow hairy skin in a dish
Researchers have successfully developed a method to grow hairy skin from mouse pluripotent stem cells -- a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers.
Stem cells sense neighborhood density to make decisions on their behavior
Human skin is a remarkable organ serving as a barrier protecting us from pathogens, toxic substances and others. Our skin needs to constantly renew throughout our lifetime as well as change its size to perfectly fit and cover the body. To fulfill such a complex and dynamic behavior every cell within the skin has a specific task dependent on its position. Scientists have now shown that cell density and crowding play a critical role in instructing single stem cell fate decisions and movement of differentiating cells upwards within the tissue. This ensures that all cell types are correctly positioned within the tissue.
How do broken bones heal?
Find out what gives our bones their remarkable ability to heal breaks in a finely tuned process that involves stem cells, cartilage, and bone.
Tags: Stem cells
Could interneuron migration explain macrocephaly?
Researchers have discovered a new crosstalk between the migrating inhibitory interneurons and the stem cells that generate the excitatory neurons. The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice.
Reprogramming adult cells into induced pluripotency with unprecedented efficiency
A team of scientists has reported a more efficient approach to reprogramming a patient's diseased skin cells into stem cells, raising hopes for future clinical trials and potential cures for critical illnesses.
Stem cells grown into 3-D lung-in-a-dishOlder articles »
By coating tiny gel beads with lung-derived stem cells and then allowing them to self-assemble into the shapes of the air sacs found in human lungs, researchers have succeeded in creating three-dimensional lung "organoids." The laboratory-grown lung-like tissue can be used to study diseases including idiopathic pulmonary fibrosis, which has traditionally been difficult to study using conventional methods.